Intestinal immunity ofEscherichia coliNISSLE 1917: a safe carrier for therapeutic molecules
نویسندگان
چکیده
منابع مشابه
A Safe Therapeutic Approach
Background Data During the last decade, we have used recombinant human growth hormone (rhGH; 0.2 mg/kg/day SQ) to successfully treat 130 children with more than 40% total body surface area (TBSA) burns to enhance wound healing and decrease protein loss. A significant increase in the mortality of adult patients in the intensive care unit who were given rhGH has recently been reported in two larg...
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The practice of immunization of animals and humans has been carried out for centuries and is generally accepted as the most cost effective and sustainable method of infectious disease control. Over the past 20 years there have been significant changes in our ability to produce antigens by conventional extraction and purification, recombinant DNA and synthesis. However, many of these products ne...
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Probiotics are viable microorganisms that are increasingly used for treatment of a variety of diseases. Occasionally, however, probiotics may have adverse clinical effects, including septicemia. Here we examined the role of the intestinal microbiota and the adaptive immune system in preventing translocation of probiotics (e.g., Escherichia coli Nissle). We challenged C57BL/6J mice raised under ...
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Atherosclerosis is considered a chronic inflammatory disease and an intervention targeting the inflammatory process could be a new therapeutic strategy for preventing atherosclerotic cardiovascular diseases (CVD). We hypothesized that the intestine, which is considered the biggest immune organ in the human body, could be a therapeutic target for preventing CVD. We demonstrated that oral adminis...
متن کاملImmunity in Intestinal Obstruction
1. There is no increased immunity or tolerance to intestinal obstruction after recovery from previous obstruction. 2. Dogs recovered from intestinal obstruction are not more resistant to injections of closed loop fluid than normal dogs. 3. Dogs injected with closed loop fluid are not more resistant to intestinal obstruction than normal dogs. 4. In dogs the normal variation in resistance both to...
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ژورنال
عنوان ژورنال: FEMS Immunology & Medical Microbiology
سال: 2005
ISSN: 0928-8244,1574-695X
DOI: 10.1016/j.femsim.2004.10.023